BASANT, A Marvellous Polyherbal Formulation that Cures Abnormal Vaginal Discharge Restoring Healthy Vagina, It Prevents Sexually Transmitted Infections such as Gonnorrhoeae, and HIV and eliminates HPV Preventing Carcinoma of Cervix

Review Article

BASANT, A Marvellous Polyherbal Formulation that Cures Abnormal Vaginal Discharge Restoring Healthy Vagina, It Prevents Sexually Transmitted Infections such as Gonnorrhoeae, and HIV and eliminates HPV Preventing Carcinoma of Cervix

G.P. Talwar ^*
Jagdish C. Gupta

Talwar Research Foundation, New Delhi, India.

*Corresponding Author: G P Talwar, Director Research, Talwar research Foundation, Neb Valley, New Delhi, India.

Citation: G.P. Talwar, Jagdish C. Gupta. (2022). BASANT, A Marvellous Polyherbal Formulation that Cures Abnormal Vaginal Discharge Restoring Healthy Vagina, It Prevents Sexually Transmitted Infections such as Gonnorrhoeae, and HIV and eliminates HPV Preventing Carcinoma of Cervix. Journal of Women Health Care and Gynaecology. 1(1);1-3. DOI: 10.59657/2993-0871.brs.23.001

Copyright: © 2022 G.P. Talwar, this is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Received: July 07, 2022 | Accepted: August 04, 2022 | Published: August 10, 2022

Abstract

While working at the All-India Institute of Medical Sciences, I learnt that a fairly large number of women suffer from abnormal vaginal discharge. Can anything be done to restore a healthy vagina?

We developed a Polyherbal formulation employing Curcumin (diferuloyl methane), Aloe vera, purified extracts of Amla (Emblica Officinalis) and Neem (Azadirachta Indica) along with pharmacopially approved excipients. This formulation was named BASANT, which in India is the spring season. Curcumin is an important ingredient of the formulation besides others, and it has yellow hue.

Keywords: polyherbal; vagina; gonnorrhoeae; HIV; HPV; carcinoma; cervix

Introduction

While working at the All-India Institute of Medical Sciences, I learnt that a fairly large number of women suffer from abnormal vaginal discharge. Can anything be done to restore a healthy vagina?

We developed a Polyherbal formulation employing Curcumin (diferuloyl methane), Aloe vera, purified extracts of Amla (Emblica Officinalis) and Neem (Azadirachta Indica) along with pharmacopially approved excipients [1]. This formulation was named BASANT, which in India is the spring season. Curcumin is an important ingredient of the formulation besides others, and it has yellow hue.

Figure 1 shows the transformation of the vagina of a woman suffering from abnormal vaginal discharge. The vaginal pH came down from 5 and above to normal 4.5. The formulation also exercised spermicidal action and the woman need not use any contraceptive device as and when she is using BASANT.

Figure 1: An illustrative representation of a typical woman suffering from recurring episodes of Vaginosis (2).

BASANT prevents the women getting undesirable genital infections, such as gonnorrhoeae and HIV.

Standard WHO strains	Antibiotic resistance	Growth at different concentrations (v/v) of Basant after 24 h
Standard WHO strains	Antibiotic resistance	5%	2%	1%	0%
N. gonorrhoeae WHO–C	None	-	+	+
N. gonorrhoeae WHO–G	Tetracycline (TRNG), nalidixic acid	-	-	-	+
N. gonorrhoeae WHO–K	Penicillin (PPNG), nalidixic acid, ciprofloxacin, ceftriaxone less sensitive	-	-	+
N. gonorrhoeae WHO–L	Penicillin (PPNG), nalidixic acid, ciprofloxacin, ceftriaxone less sensitive	-	-	-	+
N. gonorrhoeae 1586	Nalidixic acid, ciprofloxacin	-	-	-	+
N. gonorrhoeae 1669	Nalidixic acid, ciprofloxacin	-	-	+	+
N. gonorrhoeae 1794	Nalidixic acid, ciprofloxacin	-	-	+	+
N. gonorrhoeae 2182	Nalidixic acid, ciprofloxacin	-	-	-	+
N. gonorrhoeae 2436	Penicillin (PPNG), tetracycline (TRNG), nalidixic acid, ciprofloxacin	-	-	-	+
N. gonorrhoeae 2482	Penicillin (PPNG), nalidixic acid, ciprofloxacin	-	-	-	+
N. gonorrhoeae 2676	Penicillin (PPNG), tetracycline (TRNG), nalidixic acid, ciprofloxacin less sensitive	-	-	+	+

Table 1. WHO strains of Neisseria gonorrhoeae inhibited by BASANT (1).

Studies on inhibition of HIV were carried out by Gustavo Doncel at CONRAD Eastern Virginia Medical School Arlington, USA and Manoj Pastey at the University of Oregon, USA. Table 2 and Figure 2 show their findings.

Basant Dilution	% Inhibition by p24 assay in
Basant Dilution	CEM-GFP cells	P4 cells
1:1000	98	99
1:5000	89	Not calculated
1:10000	81	64
1:20000	51	53
1:40000	22	45
1:80000	Not calculated	32

Table 2: Percent inhibition of virus production by Basant in HIV-1 NL4.3-infected CEM-GFP and P4 cells (1).

Figure 2: Kinetics of HIV-1 Inhibition by BASANT in comparison to KY jelly and Enfuvirtide. TZM-bl cells were infected with HIV-1NL4-3 and then treated with either KY jelly or Basant or Enfuvirtide, hourly for four hours. HIV-1 Tat dependent β- galactosidase activity was measured at 405nm after two days. Treatment of cells with Basant is effective for up to three hours post-infection. Enfuvirtide continues to be effective at four hours post infection (3).

Human Papilloma Virus (HPV)

Another highly interesting action of BASANT is on HPV-16, which eventually causes Carcinoma of Cervix. Table 3 gives the results in 11 women. Each one of them became negative to HPV after inserting a capsule containing 245 mg of BASANT in the vagina every night for 30 days.

S.No.	Age	Parity	HPV-16 Pre-treatment	HPV-16 Post-treatment
1.	42	3+0	+VE	NEGATIVE
2.	27	4+0	+VE	NEGATIVE
3.	35	3+0	+VE	NEGATIVE
4.	28	1+1	+VE	NEGATIVE
5.	45	3+0	+VE	NEGATIVE
6.	35	4+0	+VE	NEGATIVE
7.	30	2+1	+VE	NEGATIVE
8.	45	2+0	+VE	NEGATIVE
9.	38	5+2	+VE	NEGATIVE
10.	35	3+1	+VE	NEGATIVE
11.	38	3+1	+VE	NEGATIVE

Table 3: Pre and post treatment with BASANT of HPV-16 positive patients (4).

Conclusion

Transfer of BASANT to Industry

Given the full safety and high utility of BASANT to women for curing abnormal vaginal discharge and preventing horrible sexually communicated infections, BASANT was licensed to M/s Bipha Drugs, Pallipurathukavu Jn, Kottayam, Kerala, India. It is sold as Cream as well as Capsules.

References

Talwar GP, Dar SA, Rai MK, Reddy KV, Mitra D, et al. A novel Polyherbal microbicide with inhibitory effect on bacterial, fungal and viral genital pathogens. Int J Antimicrob Agents. 2008; 32:180-185.
Publisher | Google Scholor
Kriplani A, Sehgal R, Atrey N, Singh P, Ganguli I, Sinha S, Gupta J.C, Talwar G.P. Clinical evaluation of comparative and combined effect of Polyherbal Microbicide (Basant) and selected probiotics in the treatment of recurrent Vaginosis –a Phase II placebo-controlled trial. Int J Ayur Pharma Research. 2014; 2(4):33-41
Publisher | Google Scholor
Maselko MB, Joshic RS, Prescott M, Talwar GP, Kulkarni S, Pastey MK. Basant, a Polyherbal Topical Microbicide Candidate Inhibits Different Clades of Both CCR5 and CXCR4 Tropic, Lab-Adapted and Primary Isolates of Human Immunodeficiency Virus-1 in Vitro Infection. J Virol Antivir Res 2014; 3:3
Publisher | Google Scholor
Talwar GP, Sharma R, Singh S, Das BC, Bharti AC, Sharma K, Singh P, Atrey N, Gupta JC. BASANT, a Polyherbal Safe Microbicide Eliminates HPV-16 in Women with Early Cervical Intraepithelial Lesions. Journal of Cancer Therapy. 2015; 6:1163-1166.
Publisher | Google Scholor

Delia Teresa Sponza

"Journal of BioMed Research and Reports has created a diverse portfolio in peer review process and provides a wide range scientific and medical novel papers to the scientists. This journal publishes high-quality, peer-reviewed content across all levels of professional development and corporate research and development."

Fatema Tashrifwala

I would like to thank the editorial team for their timely responses and consideration in the publication of my paper. They have been very helpful and accommodating, Lastly, being an open access journal, the published work is freely available and accessible to readers at no cost to them. I would encourage other authors to publish their research in BioRes Scientia. I am happy to be a part of BioRes Scientia Publishers.

Dr Nikhil Vitthal Dayama

I would like to thank the editorial team for their timely and prompt responses and consideration in the publication of my case report. Being an open access journal, it will be great help for the readers to learn the new things without any cost. I would encourage the authors to publish their research in BioRes Scientia and I am happy to be part of this journal.

Boubacar Ahy Diatta

I warmly thank the editorial team for the excellent work they do for continuing medical education in Dermatology. I was able to discover with joy their professionalist, their support and above all appreciate their social generosity on the access to the magazines which is free. This allows an update of scientific knowledge to the entire scientific community. I gladly recommend authors for publication in this journal.

Professor Rajko Igic

The editor of JBRR helped me during the whole process, mainly to eliminate some typographical and other errors. It hastened this publication to be published quickly. Although it is a short text, I believe that the content is important for all medical and other scientific disciplines because eventual addition of the iC citations to citation of the paper would lead to proper assessment of the author's contribution.

Dr Tewodros kassahun Tarekegn

I am thrilled to have had the opportunity to publish my research article in this prestigious journal. The entire process of peer review and publication support provided by the editorial office was exceptional, and it fortified my belief in the quality of my research study. The rigorous peer review process ensured that only the highest quality research was published, and the feedback from the reviewers was extremely helpful. I appreciate the journal's commitment to open access publication, enabling my research to reach a wider audience. The easy-to-use online platform streamlined the submission, peer review, and publication process, and I would confidently recommend this journal to any author looking for efficient, rigorous, and high-quality peer-reviewed publication.

Francis Okello Ooko

I was impressed by your author-centred approach whereby you maintained constant and timely communication with us from the time we submitted the manuscript to acceptance, each time providing critical suggestions to improve the manuscript. In addition, we are encouraged by the thoroughness of your editorial team in checking the originality and overall, quality of the work. Which I believe is very encouraging to other researchers and authors who wish to publish their work in your journals. The published work and the information imparted is freely available and accessible to a wide spectrum of readers at no cost to them. I would encourage other authors to publish their research in BioRes Scientia. I am happy to be a part of BioRes Scientia Publishers.

Dr Nidhi Sapolia

I would like to thank the editorial team of their timely response and guidance in the publication of my case report. They have been extremely helpful at all stages. Being an open access journal, it is of great help for the readers to learn new experiences in different fields, I would highly recommend this journal to authors for high quality peer-reviewed publications.

Dwight L Mckee MD CNS ABIHM

I am very impressed by the high quality of the papers published by the International Journal of Clinical and Molecular Oncology. The editors of this journal are a pleasure to work with, as they are highly responsive even to numerous last minute changes in the manuscript that I recently published with them, and the changes are made on-line the same day they are received. I highly recommend this journal to anyone working in the oncology field, and also value it as a source of cutting edge information in the field.

Kyaw Swar Thet

I would like to thank the editorial team for the opportunity to publish our case report in this prestigious journal. I am very impressed by their timely and efficient handling of the submission, peer review, and publication processes. As residents of a developing, low-income country, we greatly appreciate the discount on submission charges. I hope that as an open access journal, it will facilitate easy access for readers to update their scientific knowledge. I highly recommend this journal for high-quality, peer-reviewed publications. I express my sincere gratitude to the editorial team for their excellent work.

Michel Farah

I would like to thank the editorial team for their quick response and support. The publication support and editorial office were excellent and very helpful. I am happy to have my research article published in this prestigious journal. Our previous case report published in this journal was very successful and viewed by many physicians worldwide.