Review Article
Modern Management of Aortic Aneurysms: A Review of Endovascular Repair Strategies and Outcomes
- Naeem Hamza *
- Krish Shah
- Aldhana Ismail
- Timea Pentek
- Camille Gabay
- Navid Dadshani
- Jouhaina Abichou
- Tsampika Tsirakou
- Cristina Sichim
"Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
*Corresponding Author: Naeem Hamza, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Citation: Hamza N, Shah K, Ismail A, Pentek T, Gabay C, et al. (2026). Modern Management of Aortic Aneurysms: A Review of Endovascular Repair Strategies and Outcomes, Journal of Clinical Research and Clinical Trials, BioRes Scientia Publishers. 5(1):1-10. DOI: 10.59657/2837-7184.brs.26.064
Copyright: © 2026 Naeem Hamza, this is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: December 31, 2025 | Accepted: February 13, 2026 | Published: February 23, 2026
Abstract
This review provides an overview of the pathophysiology and epidemiology of aortic aneurysms and examines the principles and evolution of EVAR. Current endovascular techniques, including standard infrarenal EVAR, fenestrated EVAR, branched EVAR, chimney techniques, physician-modified endografts, and iliac branch devices, are discussed with emphasis on their indications and anatomical considerations. Clinical evidence from randomized trials and observational studies is reviewed to compare short-term and long-term outcomes, including perioperative morbidity and mortality, reintervention rates, endoleaks, and graft migration. EVAR shows improved early outcomes compared with open repair; long-term durability and the need for lifelong imaging surveillance remain important challenges. Limitations related to anatomical eligibility, cost, reintervention burden, and global access are also addressed. New developments in device design, imaging, computational modeling, and multidisciplinary care are explored as future directions aimed at improving durability and expanding eligibility.
Keywords: abdominal aortic aneurysm; endovascular aneurysm repair; EVAR; fenestrated EVAR; branched EVAR; chimney technique; endoleak; patient selection; long-term surveillance
Introduction
An aortic aneurysm is a dilation of the aorta caused by a weak spot in the arterial wall, most commonly affecting the abdominal and thoracic segments. An aneurysm is defined as a dilation of the artery to at least 1.5 times its normal diameter [1]. The abdominal aortic aneurysm is the most common type of aortic aneurysm, with a diameter of more than 3 cm or an increase of 1.5 to 2.0 times the normal adjacent aortic diameter [2]. Its clinical significance lies in the fact that it often remains asymptomatic until a catastrophic event such as rupture or dissection occurs, both of which are associated with mortality rates ranging from 65-85% [3]. AAA poses a significant risk of fatal rupture, particularly in older populations. AAA rupture is considered the 13th leading cause in the United States [1]. These aneurysms typically develop due to degenerative changes in the aortic wall, influenced by factors such as age, smoking, hypertension, and atherosclerosis, with a higher incidence in men aged between 65 and 80 years [4]. Historically, the open surgery has been considered the standard treatment for AAA, which involves extensive abdominal incision, aortic clamping, and graft replacement. This procedure demands prolonged anesthesia, significant recovery time, and substantial perioperative risk, especially among high-risk patients [2]. In the early 1990s, the management of aortic aneurysms significantly changed with the introduction of endovascular aneurysm repair (EVAR). EVAR introduced a minimally invasive, image-guided alternative to open surgical repair. The procedure involves introducing a stent-graft through a percutaneous or femoral arterial approach and deploying it within the aortic lumen under fluoroscopic guidance. The endograft isolates the aneurysm sac from systemic arterial pressure and reduces the risk of rupture without the need for direct surgical exposure of the aorta [5,6]. EVAR offers several advantages, such as minimal incisions, reduced operative trauma, shorter operative duration, lower intraoperative blood loss, shorter hospital stays, and faster postoperative recovery [4]. As a result, EVAR became a preferred alternative for patients considered high risk for open surgical repair. Over time, EVAR technology has advanced from basic tubular or bifurcated grafts to sophisticated fenestrated, branched, and hybrid systems, enabling treatment of complex anatomies such as juxta-renal or thoracoabdominal aneurysms that were previously considered unsuitable for standard EVAR. As a consequence of these advancements, EVAR has become the predominant method for infrarenal AAAs in most vascular centers worldwide [7]. Endovascular aneurysm repair (EVAR) has changed the way we treat abdominal aortic aneurysms by offering a less invasive alternative to open surgery. It lowers the risk of complications, shortens hospital stays, and offers a faster recovery. Improvements in graft design, such as fenestrated and branched grafts, have made EVAR possible for more complex cases. Also, long-term follow-up helps in early detection of complications such as endoleaks or graft migration. Despite these benefits, limitations such as anatomical limits, the need for lifelong monitoring, and the absence of a clear survival advantage in certain patient groups exist. These developments raise the central question of how endovascular techniques have improved AAA outcomes and what limitations remain. In this paper, we discuss how EVAR has improved patient outcomes, the limitations, the current challenges, and the future directions.
Pathophysiology and Epidemiology of Aortic Aneurysms
An aortic aneurysm is a permanent, localized dilation of the aortic wall resulting in an aortic diameter at least 50% greater than normal [8]. The pathogenesis involves progressive structural weakening of the vessel wall due to the combined effects of mechanical stress, inflammation, and underlying genetic susceptibility. The pathogenesis of aortic aneurysms frequently stems from an intrinsic weakness in the aortic wall's structural proteins, though it can also be initiated by trauma or infection. A central component of this process is the dysregulation of the extracellular matrix, characterized by a critical deficiency of elastin, a loss of collagen type I, and an altered elastin-to-collagen ratio [9]. Although atherosclerosis was historically regarded as the main cause of aneurysm formation, current evidence suggests it acts primarily as an accelerant of the degenerative process rather than its initiator. One significant pathway for this acceleration is through the formation of an intraluminal thrombus. This adherent thrombus is biologically active, creating hypoxia and serving as a source of proteases like MMP-9, which directly contribute to medial degeneration and inflammation [10]. Hemodynamic factors also play a pivotal role. Regions of turbulent flow and high wall shear stress, especially near arterial bifurcations, create focal zones of weakness where aneurysmal dilation commonly develops [11]. Over time, the aneurysm enlarges as wall tension increases, eventually predisposing the vessel to rupture. The major risk factors for developing an aortic aneurysm include age, family history, lifestyle habits, medical conditions, and sex. The aortic aneurysms are classified based on their location on the aorta – abdominal aortic aneurysm (AAA) and thoracic aortic aneurysms (TAA). Abdominal aortic aneurysm mostly affects adults over age 65, with a strong male predominance. One in 10 people with abdominal aortic aneurysms has a family history, and the chances of developing an AAA are 1 in 5 for first-degree relatives. Thoracic aortic aneurysms are often linked to connective tissue disorders like Ehlers-Danlos syndrome, Loeys-Dietz syndrome, and Marfan syndrome. The risk of developing an aortic aneurysm is elevated in individuals who smoke cigarettes, use cocaine, or have underlying conditions such as hypertension, COPD, obesity, or other cardiovascular diseases [12]. Aneurysms are frequently asymptomatic until rupture. In recent years, the incidence of ruptured aneurysms has been growing, accounting for 1-2% of all deaths [13]. Aortic aneurysms, therefore, remain a critical public health issue. A clear understanding of their biological mechanisms and epidemiological patterns together form the foundation for preventive strategies and guide the evolution of minimally invasive approaches such as Endovascular Aneurysm Repair (EVAR).
Endovascular Aneurysm Repair (EVAR) Overview
Endovascular aneurysm repair (EVAR) represents a paradigm shift in aortic aneurysm management, offering a minimally invasive alternative to open surgical repair. The procedure involves percutaneous or surgical placement of a stent graft via femoral arterial access, deployed under fluoroscopic guidance to exclude the aneurysm sac from circulation. [14] The procedure begins with percutaneous or open access to the common femoral artery, with percutaneous techniques increasingly preferred due to reduced procedural time and wound complications. [15] Large-bore vascular sheaths (18-24 French) are inserted through small punctures, allowing delivery of the stent graft system. Real-time ultrasound guidance enhances access precision and minimizes vascular injury. [16] The stent graft is a modular composite device comprising a metallic skeleton-typically nitinol, stainless steel, or cobalt-chromium-combined with fabric graft material (polytetrafluoroethylene or woven polyester). [17] The metallic component provides structural support and radial force to maintain patency, while the fabric seals to exclude blood flow into the aneurysm sac. [18] Once positioned under biplane fluoroscopic guidance using angiographic landmarks, the self-expanding stent graft deploys and conforms to aortic geometry, establishing circumferential contact for an effective seal [19]. Modular components are sequentially deployed to complete the endograft construct and achieve complete aneurysm exclusion.
The mechanism of Action involved is that EVAR prevents rupture by transferring hemodynamic load from the weakened aneurysmal wall to the rigid stent graft. Aneurysm rupture occurs when wall stress-internal biomechanical forces per unit area-exceeds the structural integrity of the degraded wall. By excluding the aneurysm sac, EVAR removes sac pressurization and reduces peak wall stress by an estimated 50-70%, substantially lowering instantaneous rupture risk [20]. Over time, reduced sac pressure promotes thrombosis and gradual remodeling with sac shrinkage. There are advantages over open repair, as EVAR demonstrates substantial short-term advantages over open repair. Meta-analysis of randomized controlled trials showed perioperative mortality of 1.5% for EVAR versus 4.6% for open surgery-a threefold mortality reduction (relative risk 0.33) [21]. EVAR patients experienced markedly reduced blood loss, fewer complications (pneumonia, acute renal failure, respiratory failure, mesenteric ischemia), and significantly shorter hospitalization. Median hospital stay was 7 days for EVAR versus 14 days for open repair (P less than 0.001), with 62.8% of EVAR patients discharged directly home. [22] Percutaneous techniques eliminate major laparotomy complications, including wound infection and fascial dehiscence. Recovery following EVAR is substantially faster, with patients typically ambulating within 24 hours and returning to normal activities within 2-4 weeks compared to 6-12 weeks for open repair. [23] Despite short-term advantages, EVAR has important long-term limitations. Meta-analysis of four major randomized trials (EVAR-1, DREAM, OVER, ACE; n=2,783 patients) demonstrated that the perioperative mortality advantage (hazard ratio 0.61) was lost by 3 years post-randomization, with no difference in 5-year overall survival. [24] Beyond 3 years, aneurysm-related mortality was significantly higher in EVAR cohorts (hazard ratio 5.16; P=0.010). Endoleaks-incomplete aneurysm sac exclusion-occur in 15-30% of patients. Type I endoleaks (inadequate seal at attachment sites) directly pressurize the sac and require urgent intervention, while Type II endoleaks (collateral backflow) often thrombose spontaneously, but hemodynamically significant examples require embolization. [25] Graft migration (displacement >10 mm) occurs in 1-10% of patients and substantially increases rupture risk, particularly with hostile neck anatomy (short neck less than 15 mm, excessive angulation >60°). [26] EVAR requires lifelong surveillance imaging (contrast-enhanced CT at 1 and 12 months, then annually) to detect complications, creating cumulative radiation exposure concerns. [27] Secondary interventions occur in approximately 10-15% of patients within 5 years and continue accruing long-term, compared to less than 5% for open repair, substantially eroding EVAR's initial cost advantage [28].
Types of Endovascular Repair
Abdominal aortic aneurysms have always posed a difficult condition to manage in vascular surgery. Standard infrarenal EVAR remains the most commonly performed approach, but due to anatomical limitations, the physicians explored alternatives that would cater to the patients according to the respective aneurysm location and anatomical variations. More advanced endovascular strategies have been introduced, giving rise to variants such as fenestrated EVAR(FEVAR), branched EVAR(BEVAR), chimney EVAR(Ch-EVAR), and iliac branch device (IBD-EVAR). Each type is developed with the aim of achieving adequate aneurysm exclusion while maintaining maximal possible blood flow to the critical vessels. The choice of approach depends on vascular anatomy, aneurysm location, etc. Each device has its respective advantages and limitations.
Standard EVAR (Infrarenal EVAR)
Standard EVAR is the most frequently used endovascular repair in the treatment of abdominal aortic aneurysm (AAA). The anatomical requirements should be carefully evaluated before the procedure: the proximal neck area should measure at least 10-15 mm of healthy, unaffected aorta, with minimal neck angulation (generally under 60°), and the femoral/iliac access vessel should have a sufficient diameter and be relatively straight enough for delivery systems. The procedure requires the insertion of a stent-graft, composed of a metallic scaffold and a covering synthetic fabric, into the femoral artery under imaging guidance. The main body of the graft will be positioned in the infrarenal aorta, where it is sealed against the aortic wall. Compared to open surgery, standard EVAR results in reduced perioperative morbidity, less physiological stress, and a reduced recovery period. However, complications such as access vessel injury, endoleak types I or II, graft migration, limb occlusion, and aneurysm sac enlargement should also be taken into consideration. Lifelong surveillance with CT is required due to the persistent risk of endoleaks and reintervention [29].
Fenestrated EVAR(FEVAR)
FEVAR is indicated in cases of short neck (less than 10-15mm), juxtarenal or suprarenal aortic aneurysm, which cannot be treated by standard endovascular repair. The stent-graft is customised with fenestrations in the proximal area that correspond with the branch vessels (renal/visceral arteries). Specialised bridging stents are then inserted through these fenestrations into the branch vessels to maintain organ perfusion. FEVAR is especially valuable for patients who are poor candidates for open surgery, as it allows preservation of visceral blood flow [30].
Branched EVAR (BEVAR)
Branched EVAR is particularly used in the case of complex thoracoabdominal aortic aneurysms (TAAAs) and extensive paravisceral aortic aneurysms where multiple visceral and renal arteries must be preserved, and standard EVAR cannot provide a suitable seal. Unlike FEVAR, which uses fenestration to line up with branch vessels, BEVAR uses stent-grafts with incorporated side branches that allow bridging stents to be deployed into the arteries. This approach allows the treatment of aneurysms that extend from the thoracic to the abdominal aorta, which traditionally requires open repair. Because BEVAR covers a long segment of the aorta, it may require additional measures such as spinal cord protection due to the high risk of ischemic complications [31].
Chimney EVAR/Snorkel (ChEVAR)
ChEVAR is indicated for juxtarenal or branch involving aneurysms when the infrarenal neck is inadequate for standard EVAR or when branched/fenestrated devices are not available. In this technique, one or more covered stents are deployed parallel to the main aortic endograft, extending from the branch vessel into the aorta to form “chimneys” projecting into the main stent-graft to maintain perfusion to renal or visceral arteries. The major technical issue with ChEVAR is the risk of “gutter” formation. Channels or spaces between the chimney stent and the main graft are formed, leading to type Ia endoleaks and a higher risk of reintervention compared to FEVAR. [32] Overviews of chimney EVAR techniques mention that this risk can be minimised by main body graft oversizing. However, even after this change, the risk of “gutter” formation remains when multiple chimney stents are used [33].
Iliac Branch Device (IBD-EVAR)
In patients who suffer from aorto-iliac aneurysms, the standard treatment is the use of an iliac branch device. IBD-EVAR uses stents with a dedicated branch that helps maintain the pelvic perfusion, while also permitting a secure distal seal within the external iliac artery. This method reduces the likelihood of pelvic ischemia, gluteal claudication, bowel ischemia, or other complications associated with bilateral internal iliac artery occlusion. However, the successful use of IBD-EVAR requires careful anatomical assessment and may not be feasible in all patients [34].
Clinical Evidence and Outcomes
Clinical Evidence and Outcomes of EVAR: Assessing clinical outcomes of Endovascular aneurysm repair is essential to evaluate its safety, efficacy, and long-term durability compared with traditional open surgical repair. This section reviews published evidence on perioperative mortality, longitudinal survival, complications, and the need for reinterventions following EVAR.
Short-term Outcomes and Perioperative Complications: EVAR is associated with lower immediate perioperative morbidity and mortality compared with open repair, particularly in high-risk populations. Acute kidney injury (AKI) is a notable complication, especially in complex aneurysm repairs involving juxtarenal, pararenal, or thoracoabdominal anatomy. A systematic review of 52 studies including 5,454 patients reported AKI incidence ranging from 0% to 41%, with temporary and permanent hemodialysis required in up to 19% and 14% of cases, respectively. Higher anatomical complexity and longer operative times were associated with increased AKI, whereas mode of repair, surgical experience, and pre-existing chronic renal insufficiency were not consistently linked to renal outcomes [35]. Other perioperative complications include cardiac, pulmonary, and bleeding events. In octogenarians undergoing elective AAA repair, EVAR significantly reduced immediate postoperative mortality (OR 0.23), overall complications (OR 0.30), and cardiac, renal, pulmonary, and bleeding complications compared with open repair, while operative time, blood loss, ICU stay, and total hospital stay were also significantly lower [36]. Similar trends were observed in thoracic and thoracoabdominal aneurysm populations, with EVAR associated with reduced paraplegia, cardiac complications, and respiratory morbidity, although vascular complications were slightly higher in endovascular cohorts [37,38]. Advanced imaging strategies such as intra-operative computed tomography (CT) have been shown to improve detection of technical complications during EVAR. A systematic review of six studies found that intra-operative CT was superior to completion angiography, allowed for earlier management of complications, and did not increase contrast-induced renal injury or radiation exposure [39].
Technical Success and Reinterventions. The technical success of EVAR is generally high. A meta-analysis of 16 studies in mainland China reported a pooled technical success rate of 95%, with an endoleak rate of 7% and only 3% of patients requiring reintervention [40]. Postoperative surveillance is critical, as aneurysm sac behavior strongly predicts outcomes. Patients demonstrating sac shrinkage at 12 months had lower hazards of death (HR 0.73), secondary interventions (HR 0.42), late complications (HR 0.37), and rupture (OR 0.09), underscoring the prognostic value of sac regression [41]. Specific complications, such as Type IIIb endoleak, though rare, are serious and associated with high rupture risk. A systematic review of 50 patients reported aneurysm sac expansion in 69% and rupture in 26% of cases. Diagnosis was challenging, and was achieved definitively in only 20% of cases via CT angiography. Most cases were successfully managed endovascularly, though some required open repair or hybrid techniques, highlighting the importance of vigilant surveillance and timely reintervention [42].
Long-term Survival and Comparison with Open Repair. Long-term survival following EVAR shows nuanced outcomes. The UK EVAR Trial 1, with a 15-year follow-up of 1,252 patients, demonstrated an early survival benefit of EVAR over open repair in the first six months. However, beyond eight years, EVAR was associated with higher total and aneurysm-related mortality, primarily due to secondary aneurysm sac rupture, emphasizing the need for lifelong surveillance [43]. Meta-analyses in thoracic and thoracoabdominal aneurysms similarly found that EVAR offers superior perioperative outcomes, including shorter hospital and ICU stays, and lower rates of paraplegia, cardiac, and respiratory complications. However, long-term mortality (1-to-5-year follow-up) was generally comparable to open repair, and dedicated randomized trials are needed to assess outcomes beyond five years [37,38].
Special Populations: Elderly and high-risk patients benefit significantly from EVAR. Octogenarians demonstrated reduced short-term mortality and complications, despite frailty and comorbidities, although long-term survival remained comparable to open repair [36]. Patients with complex aneurysms, including juxtarenal, pararenal, thoracoabdominal, and thoracic aneurysms, benefit from EVAR due to minimally invasive access and reduced perioperative morbidity, but these populations also carry higher risks of AKI and reintervention, emphasizing careful patient selection and procedural planning [35,37,38,40].
Limitations and Current Challenges
While endovascular aneurysm repair has become the standard treatment option for aortic aneurysms, it still encounters some limitations and current challenges. Several studies have compared the mortality rates between EVAR and open surgical repair. Some results showed no long-term survival difference in all-cause mortality between the two groups [44]. Other studies have reported that while outcomes of open surgical repair remain stagnant, the mortality rate for endovascular techniques is decreasing [45]. However, EVAR patients have a significantly higher risk of re-interventions due to post-procedural complications. Most re-interventions are again performed using an endovascular approach [46]. Another limitation is that, to receive an endovascular repair, patients must meet specific criteria. Eligibility primarily depends on proximal neck morphology, including neck length, diameter, and infrarenal angulation. The most common reason for ineligibility is an insufficient neck length. It has also been observed that female patients are disproportionately excluded due to less favorable aortic anatomy. Eligibility criteria also vary according to the device used [47]. With the expansion of new devices arriving on the market, more patients become eligible [48,49]. Fenestrated endovascular repair and snorkel EVAR are both methods currently used to perform an endovascular repair on patients with hostile proximal neck anatomy [49]. A major advantage of EVAR is the faster postoperative recovery compared with an open surgical repair. This implies a shorter hospital stay and fewer healthcare resources required. However, the overall cost of an EVAR intervention remains higher than that of open surgical repair. This is primarily due to the cost of the stent graft [50]. The higher likelihood of re-intervention after EVAR further contributes to long-term costs. Due to the risk of complications such as endoleak, graft infection, stent-graft migration, and thrombosis, patients require lifelong imaging surveillance [51]. This enables the early detection of possible complications or recurrent aneurysm formation. Computed tomography (CT) is the standard modality for surveillance [46]. Finally, while endovascular aneurysm repair has become the most commonly performed procedure for aortic aneurysm, this method remains largely limited to high-income countries. Indeed, in many emerging countries where EVAR is not widely available, open surgical repair remains the standard treatment option for an aortic aneurysm [52]. Overall, the evolution of EVAR has markedly improved the management of aortic aneurysms and offers significant perioperative advantages. However, persistent limitations such as reintervention rates, anatomical constraints, long-term surveillance requirements, and global disparities highlight the need for refinements. Continued device innovation and global accessibility would be beneficial to further optimize outcomes and expand the benefits of endovascular repair.
Future Directions
Future directions in EVAR are converging on one goal: expand anatomic eligibility while improving durability and reducing procedure burden. Next-generation stent grafts for EVAR use polymer sealing rings and low-profile designs, which are central to this shift. The polymer rings (as in the Ovation system) are filled inside the aorta and mold to the wall, creating a strong seal with less constant outward pressure. This helps prevent neck dilatation, endoleaks, and graft migration, even in short or angulated necks [53]. Low-profile systems can pass through small or twisted iliac arteries, so patients with difficult access can still receive EVAR. In complex cases, such as juxtarenal aneurysms, they offer a safe option when fenestrated or open surgery is not possible [54]. A second major trend is the development of the Off-the-shelf fenestrated and branched grafts. It allows fast, minimally invasive repair of complex aortic aneurysms, especially when custom devices or open surgery are not possible (e.g., emergencies). These grafts have pre-made holes or branches that line up with the renal, mesenteric, and celiac arteries. After the main graft is placed, bridging stents connect these openings to the target vessels, keeping them perfused while excluding the aneurysm. Devices like the T-Branch expand EVAR eligibility and lower short-term morbidity and mortality [55]. However, long-term durability is still being studied, and reinterventions are more common due to branch stent problems [56]. Third, Three-dimensional printing creates patient-specific aortic models from CT scans, helping doctors see complex anatomy, plan the procedure, choose devices, and even rehearse stent graft deployment, especially in difficult neck or branch anatomy [57]. Artificial intelligence planning automatically segments vessels, measures the aneurysm, finds sealing zones, and predicts risks, speeding up workflow and supporting device sizing and case selection [58]. Fusion imaging overlays 3D vascular models onto live fluoroscopy, guiding device navigation and deployment while cutting radiation, contrast use, and procedure time [59]. Together, these tools improve planning, accuracy, and safety in standard and complex endovascular aortic repair. Fourth, the predictive models based on biomechanical and computational modeling can greatly improve aneurysm rupture risk prediction and result in improvement in stent graft sizing as compared to diameter alone. Methods like finite element analysis and fluid-structure interaction utilize CT-based 3D models of the aorta to derive wall stress, wall shear stress, and deformation. These maps identify the weakest areas that are often consistent with actual rupture sites and can be integrated with features such as neck length, thrombus, and tortuosity to create individualized risk scores. These same models can simulate how a stent graft will deploy in a particular patient and influence device size, landing zones, and oversizing to maximize sealing and minimize endoleaks or migration [60]. Finally, the integration of multidisciplinary care brings together vascular surgeons, radiologists, and biomedical engineers to improve aortic aneurysm repair [61]. Vascular surgeons evaluate anatomy and risk, choose between open and endovascular repair, and perform the procedure. Radiologists provide and interpret CT, MRI, or ultrasound for diagnosis, planning, intraoperative guidance, and follow-up to detect endoleaks, migration, or sac growth. Biomedical engineers help design and refine stent grafts, modeling tools, and advanced imaging systems. This team approach is crucial for complex thoracoabdominal aneurysms and is linked to better outcomes, especially when combined with shared decision-making and lifelong imaging surveillance [62].
Conclusion
Endovascular aneurysm repair (EVAR) has become a key tool in treating aortic aneurysms today. Its minimally invasive approach has transformed care, especially for older patients or those with other health issues. As covered in this review, advances in endovascular techniques mean that not only infrarenal aneurysms but also more complex cases involving the renal and visceral arteries can be repaired. Newer options like fenestrated, branched, chimney, and physician-modified endografts have opened up treatment for patients who previously had no endovascular options. Both clinical trials and real-world studies show that EVAR leads to fewer problems and deaths right after surgery compared to open repair. Patients usually go home sooner and recover faster. But these early benefits come with some trade-offs. EVAR patients face more reinterventions over time and need lifelong imaging checkups. Issues like endoleaks, graft migration, and changes in aneurysm size are still concerns and can influence long-term results. Choosing the right patients is crucial for success. Doctors have to consider anatomy, surgical risks, and whether the device matches the patient’s needs when picking the best endovascular method. Even with all the progress in technology, there’s still limited evidence comparing complex EVAR techniques, and we don’t fully know how well they hold up beyond ten years. Looking ahead, future EVAR improvements will likely make devices last longer, make procedures simpler, and improve imaging and planning. More long-term and head-to-head studies are needed to help doctors decide which technique and follow-up plan is best. Overall, EVAR has moved aneurysm care forward in a big way, but picking the right cases and ongoing monitoring are still key to getting the best results.
References
- Calero, A., Illig, K. A. (2016). Overview of Aortic Aneurysm Management in The Endovascular Era. Seminars in Vascular Surgery. 29(1-2):3-17.
Publisher | Google Scholor - Kim, H. O., Yim, N. Y., Kim, J. K., Kang, Y. J., Lee, B. C. (2019). Endovascular Aneurysm Repair for Abdominal Aortic Aneurysm: A Comprehensive Review. Korean Journal of Radiology, 20(8):1247-1265.
Publisher | Google Scholor - Sakalihasan, N., Michel, J. B., Katsargyris, A., Kuivaniemi, H., Defraigne, J. O., et al. (2018). Abdominal Aortic Aneurysms. Nature Reviews Disease Primers, 4(1):34.
Publisher | Google Scholor - England, A., Mc Williams, R. (2013). Endovascular Aortic Aneurysm Repair (EVAR). The Ulster Medical Journal, 82(1):3.
Publisher | Google Scholor - Greenhalgh, R. M. (2004). Comparison of Endovascular Aneurysm Repair with Open Repair in Patients with Abdominal Aortic Aneurysm (EVAR Trial 1), 30-Day Operative Mortality Results: Randomised Controlled Trial. The Lancet, 364(9437):843-848.
Publisher | Google Scholor - Bryce, Y., Rogoff, P., Romanelli, D., Reichle, R. (2015). Endovascular Repair of Abdominal Aortic Aneurysms: Vascular Anatomy, Device Selection, Procedure, and Procedure-Specific Complications. Radiographics, 35(2):593-615.
Publisher | Google Scholor - Bakewell, R., Krokidis, M., Winterbottom, A. (2022). Endovascular Abdominal Aortic Aneurysm Repair: Overview of Current Guidance, Strategies, and New Technologies, Perspectives from The United Kingdom. Journal of Clinical Medicine, 11(18):5415.
Publisher | Google Scholor - Johnston, K. W., Rutherford, R. B., Tilson, M. D., Shah, D. M., Hollier, L., et al. (1991). Suggested Standards for Reporting on Arterial Aneurysms. Journal of Vascular Surgery, 13(3):452-458.
Publisher | Google Scholor - Saratzis, A., Bown, M. J. (2014). The Genetic Basis for Aortic Aneurysmal Disease. Heart, 100(12):916-922.
Publisher | Google Scholor - Sakalihasan, N., Limet, R., Defawe, O. D. (2005). Abdominal Aortic Aneurysm. The Lancet, 365(9470):1577-1589.
Publisher | Google Scholor - Sforza, D. M., Putman, C. M., Cebral, J. R. (2009). Hemodynamics of Cerebral Aneurysms. Annual Review of Fluid Mechanics, 41(1):91-107.
Publisher | Google Scholor - NHLBI. Aortic Aneurysm: Causes and Risk Factors, National Heart, Lung, and Blood Institute.
Publisher | Google Scholor - Torres-Fonseca, M., Galan, M., Martinez-Lopez, D., Cañes, L., Roldan-Montero, R., et al. (2019). Fisiopatología del aneurisma de aorta abdominal: biomarcadores y nuevas dianas terapéuticas. Clínica e Investigación en Arteriosclerosis, 31(4):166-177.
Publisher | Google Scholor - Stanford Healthcare. Endovascular Aneurysm Repair (EVAR) Procedure.
Publisher | Google Scholor - Watts M. M. (2020). Percutaneous Endovascular Aneurysm Repair: Current Status and Future Trends. Seminars in Interventional Radiology, 37(4):339-345.
Publisher | Google Scholor - Mirabella, D., Bruno, S., La Marca, M. A., Dinoto, E., Rodriquenz, E., et al. (2024). Optimizing Femoral Access in Emergency EVAR with A Decision-Making Algorithm. Life, 14(9):1113.
Publisher | Google Scholor - Sultan, S., Acharya, Y., Soliman, O., Parodi, J. C., Hynes, N. (2022). TEVAR and EVAR, The Unknown Knowns of The Cardiovascular Hemodynamics; and The Immediate and Long-Term Consequences of Fabric Material on Major Adverse Clinical Outcome. Frontiers in Surgery, 9:940304.
Publisher | Google Scholor - Hynes, N., Acharya, Y., Sultan, S. (2022). The Contemporary Design of Endovascular Aneurysm Stent-Graft Materials: PTFE Versus Polyester. Frontiers in Surgery, 9:984727.
Publisher | Google Scholor - U.S. Food and Drug Administration. Endovascular Stent Grafts: A Treatment for Abdominal Aortic Aneurysms.
Publisher | Google Scholor - Vorp, D. A., Geest, J. P. V. (2005). Biomechanical Determinants of Abdominal Aortic Aneurysm Rupture. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(8):1558-1566.
Publisher | Google Scholor - Chaikof, E. L., Brewster, D. C., Dalman, R. L., Makaroun, M. S., Illig, K. A., et al. (2009). The Care of Patients with An Abdominal Aortic Aneurysm: The Society for Vascular Surgery Practice Guidelines. Journal of Vascular Surgery, 50(4):S2-S49.
Publisher | Google Scholor - EVAR Reduces Short-, Long-term Mortality vs. Surgery for Ruptured AAA. (2013). TCTMD.
Publisher | Google Scholor - Wang Q, Wu J, Ma Y, Zhu Y, Song X, et al. (2023). Totally Percutaneous Versus Surgical Cut-Down Femoral Artery Access for Elective Bifurcated Abdominal Endovascular Aneurysm Repair. Cochrane Database Syst Rev. 1(1):CD010185.
Publisher | Google Scholor - Powell, J. T., Sweeting, M. J., Ulug, P., Blankensteijn, J. D., Lederle, F. A., et al. (2017). Meta-Analysis of Individual-Patient Data from EVAR-1, DREAM, OVER and ACE Trials Comparing Outcomes of Endovascular or Open Repair for Abdominal Aortic Aneurysm Over 5 Years. Journal of British Surgery, 104(3):166-178.
Publisher | Google Scholor - Yanamaladoddi, V. R., Sarvepalli, S. S., Vemula, S. L., Aramadaka, S., Mannam, R., et al. (2023). The Challenge of Endoleaks in Endovascular Aneurysm Repair (EVAR): A Review of Their Types and Management. Cureus, 15(5).
Publisher | Google Scholor - Ghouri, M., Krajcer, Z. (2010). Endoluminal Abdominal Aortic Aneurysm Repair: The Latest Advances in Prevention of Distal Endograft Migration and Type 1 Endoleak. Texas Heart Institute Journal, 37(1):19.
Publisher | Google Scholor - Karanikola, E., Dalainas, I., Karaolanis, G., Zografos, G., Filis, K. (2014). Duplex Ultrasound Versus Computed Tomography for The Postoperative Follow-Up of Endovascular Abdominal Aortic Aneurysm Repair. Where Do We Stand Now? International Journal of Angiology, 23(03):155-164.
Publisher | Google Scholor - Powell, J. T., Sweeting, M. J., Ulug, P., Blankensteijn, J. D., Lederle, F. A., et al. (2017). Meta-Analysis of Individual-Patient Data from EVAR-1, DREAM, OVER And ACE Trials Comparing Outcomes of Endovascular or Open Repair for Abdominal Aortic Aneurysm Over 5 Years. Journal of British Surgery, 104(3):166-178.
Publisher | Google Scholor - Kim, H. O., Yim, N. Y., Kim, J. K., Kang, Y. J., Lee, B. C. (2019). Endovascular Aneurysm Repair for Abdominal Aortic Aneurysm: A Comprehensive Review. Korean Journal of Radiology, 20(8):1247-1265.
Publisher | Google Scholor - Verhoeven, E. L. G., Katsargyris, A., Oikonomou, K., Kouvelos, G., Renner, H., et al. (2016). Fenestrated Endovascular Aortic Aneurysm Repair as A First Line Treatment Option to Treat Short Necked, Juxtarenal, and Suprarenal Aneurysms. European Journal of Vascular and Endovascular Surgery, 51(6):775-781.
Publisher | Google Scholor - Opulskis, D., Ritonga, I. T., Franke, P., Austermann, M. J., Usai, M. V. (2025). Use of Branched EVAR in Treatment of Juxtarenal Aortic Aneurysm and Essential Accessory Renal Artery: Another Tool on the Shelf? A Case Report. Vascular and Endovascular Surgery, 59(3):303-308.
Publisher | Google Scholor - Jernigan, E. G., Tran, N. N., Qato, K., Giangola, G., Carroccio, A., et al. (2021). Outcomes of Chimney/Snorkel Endovascular Repair for Symptomatic and Ruptured Abdominal Aortic Aneurysms. Journal of Vascular Surgery, 74(4):1117-1124.
Publisher | Google Scholor - Sizing of Aortic Endografts in Chimney Technique. (2019). Thoracic Key.
Publisher | Google Scholor - Giosdekos, A., Antonopoulos, C. N., Sfyroeras, G. S., Moulakakis, K. G., Tsilimparis, N., et al. (2020). The Use of Iliac Branch Devices for Preservation of Flow in Internal Iliac Artery During Endovascular Aortic Aneurysm Repair. Journal of Vascular Surgery, 71(6):2133-2144.
Publisher | Google Scholor - Liang, N. L., Mohapatra, A., Avgerinos, E. D., Katsargyris, A. (2019). Acute Kidney Injury After Complex Endovascular Aneurysm Repair. Current Pharmaceutical Design, 25(44):4686-4694.
Publisher | Google Scholor - Patel, R., Sweeting, M. J., Powell, J. T., Greenhalgh, R. M. (2016). Endovascular Versus Open Repair of Abdominal Aortic Aneurysm in 15-Years' Follow-Up of The UK Endovascular Aneurysm Repair Trial 1 (EVAR Trial 1): A Randomised Controlled Trial. The Lancet, 388(10058):2366-2374.
Publisher | Google Scholor - Hansrani, V., Halim, U. A., Goel, R. R., Antoniou, G. A. (2020). Intra-Operative Computed Tomography in Endovascular Aneurysm Repair. Vasa. 49(3):167-174.
Publisher | Google Scholor - Li, Y., He, C., Zhang, H., Zhang, X., Zhang, X., et al. (2023). Endovascular Repair for Abdominal Aortic Aneurysm in Mainland China: A Systematic Review and Meta-Analysis. Annals of Vascular Surgery, 89:338-352.
Publisher | Google Scholor - Harky, A., Chan, J. S. K., Wong, C. H. M., Bashir, M. (2019). Open Versus Endovascular Repair of Descending Thoracic Aortic Aneurysm Disease: A Systematic Review and Meta-Analysis. Annals of Vascular Surgery, 54:304-315.
Publisher | Google Scholor - Wang, G., Sun, Y., Lin, Z., Fei, X. (2023). Elective Endovascular vs Open Repair for Elective Abdominal Aortic Aneurysm in Patients≥ 80 Years of Age: A Systematic Review and Meta-Analysis. Vascular and Endovascular Surgery, 57(4):386-401.
Publisher | Google Scholor - Ellahi, A., Shaikh, F. N., Kashif, H., Khan, H., Ali, E., et al. (2022). Effectiveness of Endovascular Repair Versus Open Surgery for The Treatment of Thoracoabdominal Aneurysm: A Systematic Review and Meta Analysis. Annals of Medicine and Surgery, 81:104477.
Publisher | Google Scholor - Duric, B., Hadjihannas, I., Sugumaran, S., Jagic, K., Patel, B. (2024). Laparoscopy Versus Endovascular Aneurysm Repair for Abdominal Aortic Aneurysm: A Systematic Review. Catheterization and Cardiovascular Interventions, 104(2):300-317.
Publisher | Google Scholor - Antoniou, G. A., Alfahad, A., Antoniou, S. A., Torella, F. (2020). Prognostic Significance of Aneurysm Sac Shrinkage After Endovascular Aneurysm Repair. Journal of Endovascular Therapy, 27(5):857-868.
Publisher | Google Scholor - Chen, Z. G., Tan, S. P., Diao, Y. P., Wu, Z. Y., Miao, Y. Q., et al. (2019). The Long-Term Outcomes of Open and Endovascular Repair for Abdominal Aortic Aneurysm: A Meta-Analysis. Asian Journal of Surgery, 42(10):899-906.
Publisher | Google Scholor - Tenorio, E. R., Dias-Neto, M. F., Lima, G. B. B., Estrera, A. L., Oderich, G. S. (2021). Endovascular Repair for Thoracoabdominal Aortic Aneurysms: Current Status and Future Challenges. Annals of Cardiothoracic Surgery, 10(6):744.
Publisher | Google Scholor - Daye, D., Walker, T. G. (2018). Complications of Endovascular Aneurysm Repair of The Thoracic and Abdominal Aorta: Evaluation and Management. Cardiovascular Diagnosis and Therapy, 8(Suppl 1):S138.
Publisher | Google Scholor - Panthofer, A. M., Olson, S. L., Rademacher, B. L., Grudzinski, J. K., Chaikof, E. L., et al. (2021). Anatomic Eligibility for Endovascular Aneurysm Repair Preserved Over 2 Years of Surveillance. Journal of Vascular Surgery, 74(5):1527-1536.
Publisher | Google Scholor - Giannopoulos, S., Kokkinidis, D. G., Armstrong, E. J. (2020). Long-Term Outcomes of Endovascular vs Open Surgical Repair for Abdominal Aortic Aneurysms: A Meta-Analysis of Randomized Trials. Cardiovascular Revascularization Medicine, 21(10):1253-1259.
Publisher | Google Scholor - Yoon, W. J. (2019). Fenestrated Endovascular Aneurysm Repair Versus Snorkel Endovascular Aneurysm Repair: Competing Yet Complementary Strategies. Vascular Specialist International, 35(3):121.
Publisher | Google Scholor - Michel, M., Becquemin, J. P., Marzelle, J., Quelen, C., Durand-Zaleski, I. (2018). Editor's Choice-A Study of The Cost-Effectiveness of Fenestrated/Branched EVAR Compared with Open Surgery for Patients with Complex Aortic Aneurysms at 2 Years. European Journal of Vascular and Endovascular Surgery, 56(1):15-21.
Publisher | Google Scholor - Kazimierczak, W., Serafin, Z., Kazimierczak, N., Ratajczak, P., Leszczyński, W., et al. (2019). Contemporary Imaging Methods for The Follow-Up After Endovascular Abdominal Aneurysm Repair: A Review. Videosurgery and Other Miniinvasive Techniques, 14(1):1-11.
Publisher | Google Scholor - Shiferaw, A. A., Woldemichael, T., Woldemichael, T. K. (2025). Perioperative Management and Outcomes of Open Aortic Aneurysm Repair in Ethiopia. Cureus, 17(9):e93560.
Publisher | Google Scholor - Mathlouthi, A., Yei, K., Barleben, A., Al-Nouri, O., Malas, M. B. (2021). Polymer Based Endografts Have Improved Rates of Proximal Aortic Neck Dilatation and Migration. Annals of Vascular Surgery, 77:47-53.
Publisher | Google Scholor - de Donato, G., Pasqui, E., Mele, M., Panzano, C., Giannace, G., et al. (2020). The Use of a Low-Profile Stent Graft with A Polymer Ring Sealing Technology Combined with Bare Renal Stent (Vent Technique) in Patients with Juxtarenal Aneurysm Not Eligible for Open Surgery and Fenestrated Endograft. Journal of Vascular Surgery, 71(6):1843-1850.
Publisher | Google Scholor - Konstantinou, N., Antonopoulos, C. N., Jerkku, T., Banafsche, R., Koelbel, T., et al. (2020). Systematic Review and Meta-Analysis of Published Studies on Endovascular Repair of Thoracoabdominal Aortic Aneurysms with the T-Branch Off-The-Shelf Multibranched Endograft. Journal of Vascular Surgery, 72(2):716-725.
Publisher | Google Scholor - Gallitto, E., Faggioli, G. L., Cappiello, A., Caputo, S., Mascoli, C., et al. (2025). Ten-Year Experience in The Endovascular Repair of Complex and Thoracoabdominal Aortic Aneurysms by An Off-The-Shelf Multibranched Thoracoabdominal Endograft. Journal of Vascular Surgery. 81(6):e300-e301.
Publisher | Google Scholor - Tam, M. D., Laycock, S. D., Brown, J. R., Jakeways, M. (2013). 3D Printing of An Aortic Aneurysm to Facilitate Decision Making and Device Selection for Endovascular Aneurysm Repair in Complex Neck Anatomy. Journal of Endovascular Therapy, 20(6):863-867.
Publisher | Google Scholor - Robbi, E., Ravanelli, D., Allievi, S., Raunig, I., Bonvini, S., et al. (2025). Automatic CTA Analysis for Blood Vessels and Aneurysm Features Extraction in EVAR Planning. Scientific Reports, 15(1):16431.
Publisher | Google Scholor - Jones, D. W., Stangenberg, L., Swerdlow, N. J., Alef, M., Lo, R., et al. (2018). Image Fusion and 3-Dimensional Roadmapping in Endovascular Surgery. Annals of Vascular Surgery, 52:302-311.
Publisher | Google Scholor - Raut, S. S., Chandra, S., Shum, J., Finol, E. A. (2013). The Role of Geometric and Biomechanical Factors in Abdominal Aortic Aneurysm Rupture Risk Assessment. Annals of Biomedical Engineering, 41(7):1459-1477.
Publisher | Google Scholor - Swart, M., McCarthy, R. (2019). Shared Decision Making for Elective Abdominal Aortic Aneurysm Surgery. Clinical Medicine, 19(6):473-477.
Publisher | Google Scholor - Vilacosta, I., San Román, J. A., di Bartolomeo, R., Eagle, K., Estrera, A. L., et al. (2021). Acute Aortic Syndrome Revisited: JACC State-Of-The-Art Review. Journal of the American College of Cardiology, 78(21):2106-2125.
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